We study how epigenetics enables the formation and functioning of the human body.
We perform bioinformatic analyses of data produced in our own bench experiments.
Our long term goal is to contribute to the development and application of therapies that cure aging-associated diseases including cancer.
We study epigenetic memory during development, aging and cancer.
We are a multidisciplinary group led by Dr. David Landeira and affiliated to the Department of Biochemistry and Molecular Biology II at University of Granada. Our lab is based at the Centre for Genomics and Oncological Research (GENYO) that is co-funded by Pfizer, University of Granada and the Andalusian Regional Government.
The Landeira lab is driven by the belief that many aspects of human health are not genetically predetermined. We hypothesize that the onset of aging-associated diseases is partly a consequence of the deterioration of the cellular epigenetic memory, eventually leading to changes in cell identity and the onset of aging-associated diseases including cancer. We are currently developing different research lines to contribute to establish the molecular foundation of epigenetic memory, to identify which are the key epigenetic pathways that drive aging and cancer progression, and to develop new therapies that reverse aging-associated diseases.
Figure 1. Scheme summarizing the general research interest of the Landeira lab in epigenetics during development and in human disease.
We have extensive expertise using molecular and cell biology tools combined with emerging bioinformatics platforms to study the impact of epigenetic memory in embryo development and human disease. We use embryonic stem cells to study the role of epigenetics during embryo development, and human cell lines, patient samples and mouse models to study the function of epigenetic factors during aging and cancer progression.
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